CCR4, HTLV-1 infection, and ATL oncogenesis
نویسندگان
چکیده
منابع مشابه
Forefront studies on HTLV-1 oncogenesis
1 Equipe Oncogenèse Rétrovirale, CIRI Inserm U1111-CNRS UMR5308, Paris, France 2 Equipe Labellisée “Ligue Nationale Contre le Cancer”, CIRI Inserm U1111-CNRS UMR5308, Paris, France 3 International Center for Research in Infectiology, INSERM U1111 CNRS UMR5308, Paris, France 4 Ecole Normale Supérieure de Lyon, Lyon, France 5 Université Lyon 1, Lyon, France 6 Laboratory of Tumor Cell Biology, Dep...
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Objective(s): Human T cell leukaemia virus type 1 (HTLV-1) is associated with adult T cell leukaemia (ATL), a malignant lymphoproliferative disease that infects CD4 T cells. It is not clear why the majority of HTLV-1-infected individuals remain asymptomatic carries (ACs) and a minority develop ATL. Cellular immune response has a critical role in ATL and destroys malign...
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Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia (ATL). The minus strand of HTLV-1 provirus encodes a bZIP protein donated as HTLV-1 bZIP factor (HBZ). Among the HTLV-1 regulatory and accessory genes, the tax and HBZ genes were thought to play critical roles in oncogenesis. However, HBZ is the only gene that remains intact and is consistently expressed in all ATL cases, ...
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Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia (ATL) and chronic inflammatory diseases. HTLV-1 bZIP factor (HBZ) is transcribed as an antisense transcript of the HTLV-1 provirus. Among the HTLV-1-encoded viral genes, HBZ is the only gene that is constitutively expressed in all ATL cases. Recent studies have demonstrated that HBZ plays an essential role in oncogenesis b...
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Adult T-cell leukemia/lymphoma (ATL), a human T-lymphotropic virus type 1 (HTLV-1)-associated disease, has a highly variable clinical course and four subtypes with therapeutic and prognostic implications. However, there are overlapping features between ATL subtypes and between ATL and nonmalignant (non-ATL) HTLV-1 infection complicating diagnosis and prognostication. To further refine the diagn...
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ژورنال
عنوان ژورنال: Uirusu
سال: 2008
ISSN: 0042-6857
DOI: 10.2222/jsv.58.125